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Immunity and Immunosenescence​

Various Determinants of Immunity​

  • Intrinsic and extrinsic major factors (including determinants) which contribute to immune heterogeneity.​

Source: https://elifesciences.org/articles/90091#content Aisha Souquette, Paul G Thomas (2024) Variation in the basal immune state and implications for disease eLife 13:e90091.

Difficulties in evaluating immunity

  • The human immune system is composed of various immune cells and proteins.​

  • Immunity is expressed as the individual and organic sum of their immune functions.​

AImmuneLink’s Aim for Development of Immunity Analysis and Measurement Testing ​

  • In association with the role of 'immune T cells', especially 'exhausted T cells' among immune cells in the blood related to immunity assessment and immune aging, we aim to develop assay panels for Immunity Analysis and Measurement Testing based on the identification of proteome markers.

Immunosenescence

  • Immune aging is associated with reduced efficacy of vaccination and increased susceptibility to infectious diseases, cancer, neurodegenerative diseases including dementia, cardiovascular diseases, hypertension, diabetes and metabolic diseases, autoimmune diseases, etc.

  • Various factors affecting Immunosenescence.

Source: https://pmc.ncbi.nlm.nih.gov/articles/PMC7665974/ Xu W, Wong G, Hwang YY, Larbi A. The untwining of immunosenescence and aging. Semin Immunopathol. 2020 Oct;42(5):559-572.